| ncRNA name | hsa-miR-21 |
| ncRNA Category | miRNA |
| Disease name | granular corneal dystrophy type 2 (GCD2) |
| Species | Homo sapiens |
| Tissues/Cell_line | primary corneal fibroblasts |
| Methods | qRT-PCR, Western blot |
| Expression pattern | associated |
| Functional description | TGFBIp levels in corneal fibroblasts are controlled via the coordinated activity of miR-21 and miR-181a and by Smad signaling. Pharmacologic modulation of these miRNAs and TGF-β signaling could have therapeutic potential for TGFBI-associated corneal dystrophy, including GCD2. |
| PubMed ID | 26915797 |
| Year | 2016 |
| Title | TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling. |
| Drug-related ncRNA | NO |
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